PITSLRE (K20) polyclonal Antibody | BS1951

PITSLRE (K20) polyclonal Antibody | BS1951 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The PITSLRE β1 protein, a distantly related member of the Cdk family of protein kinases, induces apoptosis after low levels of ectopic expression. Apoptosis, or programmed cell death, is similarly induced by ectopic expression of an amino terminal deletion mutant retaining the catalytic and carboxy terminal domains of PITSLRE β1, but not by other mutants lacking Histone H1 kinase activity or by other Cdk family members. The terminology for the ten isoforms of the PITSLRE subfamily of proteins is based on the conserved PSTAIRE box region of Cdc2 p34. Depending on which of the PITSLRE genes produce the protein, the cDNA and protein are designated α, β or γ (i.e., PITSLRE A gene, α; PITSLRE B gene, β and PITSLRE C gene, γ) . Some of the isoforms such as PITSLRE α1 (T cells) and PITSLRE β1 (B cells and brain), are expressed in specific cell types, while others are expressed ubiquitously.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PITSLRE (K20) polyclonal Antibody detects endogenous levels of PITSLRE protein.

Molecular Weight: ~ 110,92 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-dependent kinase 11B; Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1; CDK11B; CDC2L1; CDK11; PITSLREA; PK58

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human PITSLRE.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A