PITX2 Antibody| F43443-0.08ML/F43443-0.4ML/RQ5602

PITX2 Antibody| F43443-0.08ML/F43443-0.4ML/RQ5602 | Gentaur UK, US & Europe Distribution

Background: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the PITX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This PITX2 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 42-71 from the human protein was used as the immunogen for this PITX2 antibody.

Storage: Aliquot the PITX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A