PKAβ cat polyclonal Antibody | BS8469

PKAβ cat polyclonal Antibody | BS8469 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PKAβ cat polyclonal Antibody detects endogenous levels of PKAβ cat protein.

Molecular Weight: ~ 40kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: cAMP-dependent protein kinase catalytic subunit beta; PRKACB; PKA C beta; PKA C-beta; PKACB; PKA Cβ

Immunogen: Recombinant full length Human PKAβ cat.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: