PKCζ (Phospho-T560) polyclonal Antibody | BS94052

PKCζ (Phospho-T560) polyclonal Antibody | BS94052 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:1,000-1:5,000 IHC:1:50-1:200

Background: Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (α, βI, βII, γ, δ, ε, Ω, h, θ, λ/ι, ? and n) . Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC δ and ε are independent of Ca++. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PKCζ (Phospho-T560) polyclonal Antibody detects endogenous levels of PKCζ protein only when phosphorylated at T560.

Molecular Weight: 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PRKCZ, PKC2, 14-3-3-zetaisoform, AI098070, aPKCzeta, C80388, EC 2.7.11.13, KPCZ, nPKC zeta, nPKC-zeta, OTTHUMP00000001368, OTTHUMP00000044160, PKC 2, PKC ZETA, PKC2, Pkcz, PKCZETA, PKM-zeta, included, PRKCZ, Protein kinase C zeta, Protein kinase C zeta form, Protein kinase C zeta type, r14-3-3, R74924, zetaPKC,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr560 of human PKC zeta.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: