PKM2 polyclonal Antibody | BS91087

PKM2 polyclonal Antibody | BS91087 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC

Application Range: WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200

Background: In mammals, four different isoenzymes exist for pyruvate kinase. Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKM (pyruvate kinase, muscle) gene encodes the M1- and M2-type isoenzymes through alternative splicing events. Both M1- and M2-type isoforms exists as tetramers and are stimulated by fructose 1,6-bisphosphate. In addition, both isoforms exhibit thyroid hormone binding activity and may be referred to as CTHBP (cytosolic thyroid hormone-binding protein) or THBP1. The M2-type isoform also interacts with Oct-4 via its C-terminal domain, functioning to enhance Oct-4 transcriptional activity. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: PKM2 polyclonal Antibody detects endogenous levels of PKM2 protein.

Molecular Weight: 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CTHBP, OIP-3, THBP1, PKM, OIP3, PK2, PK3, PKM2, CTHBP, Cytosolic thyroid hormone binding protein, Cytosolic thyroid hormone-binding protein, KPYM, MGC3932, OIP 3, OIP-3, OIP3, OPA interacting protein 3, Opa-interacting protein 3, p58, PK muscle type, PK, muscle type, PK2, PK3, PKM, PKM2, pykm, Pyruvate kinase 2/3, Pyruvate kinase 3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Pyruvate kinase muscle isozyme, pyruvate kinase PKM, Pyruvate kinase, muscle 2, TCB, THBP1, Thyroid hormone binding protein 1, Thyroid hormone binding protein cytosolic, Thyroid hormone-binding protein 1, Tumor M2 PK, Tumor M2-PK,

Immunogen: Synthetic peptide within human PKM2 aa 380-430.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: