BW
Plakophilin 2 (P663) polyclonal Antibody | BS3368
- SKU:
- BW-BS3368
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- Usually ships in 5 working days
Description
Plakophilin 2 (P663) polyclonal Antibody | BS3368 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress) . Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Plakophilin 2 (P663) polyclonal Antibody detects endogenous levels of Plakophilin 2 protein.
Molecular Weight: ~ 97 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Plakophilin-2; PKP2
Immunogen: Synthetic peptide, corresponding to amino acids 634-680 of Human Plakophilin 2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: