PLOD2 polyclonal Antibody | BS8602

PLOD2 polyclonal Antibody | BS8602 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:100

Background: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PLOD2 polyclonal Antibody detects endogenous levels of PLOD2 protein.

Molecular Weight: ~ 85kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Lysyl hydroxylase 2; LH2; PLOD2

Immunogen: Recombinant full length Human PLOD2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: