PLSCR1 polyclonal Antibody | BS8540

PLSCR1 polyclonal Antibody | BS8540 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PLSCR1 polyclonal Antibody detects endogenous levels of PLSCR1 protein.

Molecular Weight: ~ 35kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Phospholipid scramblase 1; PL scramblase 1; Ca (2+) -dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b

Immunogen: Recombinant full length Human PLSCR1.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A