PMEPA1 Antibody | 8261

PMEPA1 Antibody | 8261 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: PMEPA1 antibody was raised against a 16 amino acid peptide near the center of human PMEPA1.
The immunogen is located within amino acids 160 - 210 of PMEPA1.

Research Area: Cancer, Signal Transduction

Tested Application: E, WB, IHC-P

Application: PMEPA1 antibody can be used for detection of PMEPA1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: PMEPA1 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all of the isoforms.

Positive Control 1: Cat. No. 1203 - A549 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 26, 28, 32 kDa
Observed: 27 kDa

Validation: N/A

Isoform: N/A

Purification: PMEPA1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PMEPA1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PMEPA1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Prostate transmembrane protein androgen induced 1, STAG1, TMEPAI

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The prostate transmembrane protein, androgen induced 1 (PMEPA1) protein is a transmembrane protein that contains a Smad interacting motif (SIM) (1, 2) . Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins (3) . Overexpression of this gene may play a role in multiple types of cancer (2, 4) .