POLR3B polyclonal Antibody | BS61708

POLR3B polyclonal Antibody | BS61708 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: RNA polymerase II (Pol II) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA. POLR3B (polymerase (RNA) III (DNA directed) polypeptide B), also known as C128 or RPC2, is a 1,133 amino acid protein that localizes to the nucleus and belongs to the RNA polymerase β chain family. Existing as the second largest component of the multi-protein RNA polymerase III (Pol III) complex, POLR3B functions as a DNA-dependent RNA polymerase that specifically catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. The gene encoding POLR3B maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: POLR3B polyclonal Antibody detects endogenous levels of POLR3B protein.

Molecular Weight: ~ 127 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DNA-directed RNA polymerase III subunit RPC2; RNA polymerase III subunit C2; C128; DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit B; POLR3B

Immunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human POLR3B.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: