PPIL2 Antibody (C-term) [AMM07285G]

PPIL2 Antibody (C-term) [AMM07285G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PPIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-431 amino acids from the C-terminal region of human PPIL2.

Cellular Localisation: Nucleus. Note=May also localize to the cytoplasm and the cell membrane.

Molecular Weight: 58823

Clone: Polyclonal

Gene Name: PPIL2 (HGNC:9261)

Gene ID: 23759

Function: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423) . May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952) . Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity (PubMed:20676357) .

Summary: Tissue Location: Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells) . Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Peptidyl-prolyl cis-trans isomerase-like 2, PPIase, PPIL2 (HGNC:9261)