PR (phospho-S190) polyclonal Antibody | BS4158

PR (phospho-S190) polyclonal Antibody | BS4158 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen inducible promoters within a single copy of the PR gene. The PR-A and PR-B proteins are 90 kDa and 118 kDa respectively; the first 164 amino acids of PR-B are absent in PR-A. Progesterone bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand dependent transdominant repressor of steroid hormone receptor transcriptiona activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Progesterone Receptor (S190) polyclonal Antibody detects endogenous levels of Progesterone Receptor protein only when phosphorylated at Ser190.

Molecular Weight: ~ 90 kDa (PR-A) ~ 118 kDa (PR-B)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NR3C3; PGR; PRGR; Progesterone receptor

Immunogen: Synthetic phosphopeptide derived from human PR around the phosphorylation site of Serine 190.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phosphoinosotode Signaling,PI3K AKT signaling,Translational Contral elF4 and p70 S6 Kinase,Regulation of Microtubule Dynamics,Inhibition of Apoptosis,Insulin &Glucose Signaling,MTOR signaling,