PRAME polyclonal Antibody | BS8230

PRAME polyclonal Antibody | BS8230 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Several tumor-associated antigen families, such as MAGE, GAGE, PRAME and BAGE, are of interest in tumor immunology because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells. The MAGE, BAGE and GAGE genes code for distinct antigens that are recognized by autologous cytolytic T lymphocytes. Many of these antigens represent suitable targets for tumor immunotherapy because their expression in human melanoma cells is common and highly specific. PRAMEL (preferentially expressed antigen in melanoma-like), also known as leucine-rich repeat-containing protein PRAME-like, is a 520 amino acid protein that belongs to the PRAME family.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PRAME polyclonal Antibody detects endogenous levels of PRAME protein.

Molecular Weight: ~ 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma; PRAME; MAPE; OIP4

Immunogen: Recombinant full length Human PRAME.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: