PRDM16 Antibody (Center) [APR32933G]

PRDM16 Antibody (Center) [APR32933G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This PRDM16 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 771-804 amino acids from the Central region of human PRDM16.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 140251

Clone: Polyclonal

Gene Name: PRDM16 (HGNC:14000)

Gene ID: 63976

Function: Binds DNA and functions as a transcriptional regulator (PubMed:12816872) . Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity) . Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity) . Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity) . Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity) . Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity) . Functions as a repressor of TGF-beta signaling (PubMed:19049980) .

Summary: Tissue Location: Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1, PRDM16, KIAA1675, MEL1, PFM13