PRDM8 Antibody (N-term) [APR31446G]

PRDM8 Antibody (N-term) [APR31446G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PRDM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the N-terminal region of human PRDM8.

Cellular Localisation: Nucleus.

Molecular Weight: 71663

Clone: Polyclonal

Gene Name: PRDM8

Gene ID: 56978

Function: Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity) . Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity) . Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity) . In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity) .

Summary: Tissue Location: Expressed in brain, heart, skeletal muscle, testes, prostate.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PR domain zinc finger protein 8, 211-, PR domain-containing protein 8, PRDM8, PFM5