Pristimerin | B3238

Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Pristimerin inhibits inflammation and tumor angiogenesis and significantly reduces vessel density in synovial membrane tissues of inflamed joints and reduces the expression of pro-angiogenic factors in sera, including TNF-α, Ang-1, and MMP-9.

Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Pristimerin inhibits inflammation and tumor angiogenesis and significantly reduces vessel density in synovial membrane tissues of inflamed joints and reduces the expression of pro-angiogenic factors in sera, including TNF-α, Ang-1, and MMP-9.

B3238 | Pristimerin DataSheet

Alternate Name/Synonyms: Celastrol methyl ester,(9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester

Appearance: Orange solid

Formulation:

CAS Number: 1258-84-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₄₀O₄

Molecular Weight: 464.64

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and reversible monoacylglycerol lipase (MGL) inhibitor

MDL Number: MFCD01711331

PubChem CID: 159516

SMILES: CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)OC)C)C)C)C)O

InChi: InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1

InChi Key: JFACETXYABVHFD-WXPPGMDDSA-N