PRKCDBP Antibody (Center) [APR06012G]

PRKCDBP Antibody (Center) [APR06012G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PRKCDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from the Central region of human PRKCDBP.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner.

Molecular Weight: 27701

Clone: Polyclonal

Gene Name: CAVIN3 (HGNC:9400)

Gene ID: 112464

Function: Regulates the traffic and/or budding of caveolae (PubMed:19262564) . Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity) .

Summary: Tissue Location: Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level) . Strongly expressed in mammary and epithelial cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC, PRKCDBP, SRBC