PRRX1 Antibody | 8093

PRRX1 Antibody | 8093 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Chicken: (100%)

Immunogen: PRRX1 antibody was raised against a 19 amino acid peptide near the center of human PRRX1.
The immunogen is located within amino acids 70 - 120 of PRRX1.

Research Area: Cancer, Cell Cycle, Stem Cell

Tested Application: E, WB

Application: PRRX1 antibody can be used for detection of PRRX1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 27 kDa
Observed: 26 kDa

Validation: N/A

Isoform: N/A

Purification: PRRX1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PRRX1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PRRX1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Paired related homeobox 1, homeobox protein PHOX1, Paired mesoderm homeobox protein 1, PHOX1, PMX1, PRX1, PRX-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1, 2) . PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3) . Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4) . Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5) .