PSI-7977 | 2715

PSI-7977 is a phosphoramidate nucleotide prodrug for the treatment of hepatitis virus. It acts as a selective inhibitor of hepatitis C virus (HCV) NS5B polymerase.

PSI-7977 is a phosphoramidate nucleotide prodrug for the treatment of hepatitis virus. It acts as a selective inhibitor of hepatitis C virus (HCV) NS5B polymerase.

2715 | PSI-7977 DataSheet

Alternate Name/Synonyms: (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; Sofosbuvir; brand name: Sovaldi and Virunon.

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1190307-88-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₉FN₃O₉P

Molecular Weight: 529.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 20 mg/ml) or EtOH (~ 20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Aselective inhibitor of hepatitis C virus (HCV) NS5B polymerase.

MDL Number: N/A

PubChem CID: 45375808

SMILES: CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

InChi: InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1

InChi Key: TTZHDVOVKQGIBA-IQWMDFIBSA-N