PT1 | B2035

PT1 is an AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Directly activates AMPK by antagonizing autoinhibition.

PT1 is an AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Directly activates AMPK by antagonizing autoinhibition.

B2035 | PT1 DataSheet

Alternate Name/Synonyms: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]meth-ylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid

Appearance: Brown solid

Formulation: N/A

CAS Number: 331002-70-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₆ClN₃O₆S

Molecular Weight: 497.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An AMPK activator

MDL Number: N/A

PubChem CID: 5753734

SMILES: CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=O)N=C(S3)NC4=CC(=C(C=C4)Cl)C(=O)O)[N+](=O)[O-])C

InChi: InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10-

InChi Key: RTHRCOIONCZINZ-JMIUGGIZSA-N