PTGDR Antibody (C-Term) [APR33580G]

PTGDR Antibody (C-Term) [APR33580G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PTGDR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-348 amino acids from human PTGDR.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 40271

Clone: Polyclonal

Gene Name: PTGDR

Gene ID: 5729

Function: Receptor for prostaglandin D2 (PGD2) . The activity of this receptor is mainly mediated by G (s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1, 4, 5-trisphosphate (By similarity) . Involved in PLA2G3- dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity) .

Summary: Tissue Location: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Prostaglandin D2 receptor, PGD receptor, PGD2 receptor, Prostanoid DP receptor, PTGDR