PTGDS polyclonal Antibody | BS7694

PTGDS polyclonal Antibody | BS7694 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Human PGD synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. This enzyme is the first member of the sigma class glutathione S-transferases (GST) from vertebrates and contains a prominent cleft as the active site, which is unique among members of the GST superfamily. The human PGD synthase gene, which maps to chromosome 4q22.3, is expressed in a species-specific manner. For instance, the human gene is widely distributed, whereas the mouse gene is only expressed in oviduct and skin. Human PGD synthase is expressed in the cytoplasm of human megakaryoblastic CMK cells prior to differentiation into platelets, which have no PGD synthase activity. Another member of the PGD synthase family, PGD2 synthase, catalyzes the conversion of PGH2 to PGD2 and is essential for the synthesis of PGD2 in the brain. Unlike PGD synthase, PGD2 synthase is not dependent on the presence of glutathione for its activity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PTGDS polyclonal Antibody detects endogenous levels of PTGDS protein.

Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Beta trace protein; Beta-trace protein; Cerebrin 28; Cerebrin-28; Glutathione independent PGD synthetase; Glutathione-independent PGD synthase; L PGDS; Lipocalin type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; LPGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D2 synthase (21 kDa, brain) ; prostaglandin D2 synthase (brain) ; Prostaglandin D2 synthase; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; PTGDS; PTGDS_HUMAN; RP23-47P18.11-006;

Immunogen: Recombinant full length Human PTGDS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: