PTGS1 Antibody | 22-876

PTGS1 Antibody | 22-876 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human PTGS1 (NP_001258094.1) .

Research Area: Cancer, Immunology, Innate Immunity, Signal Transduction

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:2000
IHC: 1:100 - 1:200
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: HL-60

Positive Control 2: A-549

Positive Control 3: HT-29

Positive Control 4: THP-1

Positive Control 5: Mouse lung

Positive Control 6: Mouse liver

Molecular Weight: Observed: 69kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: PTGS1, COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, PES-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.