PTPN12 Antibody (C-Term) [AMM07395G]

PTPN12 Antibody (C-Term) [AMM07395G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PTPN12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 681-714 amino acids from human PTPN12.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.

Molecular Weight: 88106

Clone: Polyclonal

Gene Name: PTPN12

Gene ID: 5782

Function: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503) . Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172) . Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Tyrosine-protein phosphatase non-receptor type 12, 3.1.3.48, PTP-PEST, Protein-tyrosine phosphatase G1, PTPG1, PTPN12