PTPN2 polyclonal Antibody | BS6716

PTPN2 polyclonal Antibody | BS6716 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background: T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme. The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER. The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction. The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PTPN2 polyclonal Antibody detects endogenous levels of PTPN2 protein.

Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Protein tyrosine phosphatase non receptor type 2; PTN2; PTPN 2; PTPN2; PTPT; T cell protein tyrosine phosphatase; TC PTP; TCELLPTP; Tyrosine protein phosphatase non receptor type 2;

Immunogen: Recombinant full length Human PTPN2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: DNA Methylation,