PTPRC Antibody | XW-7814

PTPRC Antibody | XW-7814 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human

Homology: N/A

Immunogen: 482-552

Research Area: Other

Tested Application: WB

Application: Leukocyte common antigen antibody can be used for the detection of Leukocyte common antigen by Western Blot.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 147.3 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Immunoaffinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: PTPRC antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, LCA, LY5, B220, CD45, T200, CD45R, GP180, CD45 antigen

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: FUNCTION: Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

DISEASE: Defects in PTPRC are a cause of autosomal recessive severe combined immunodeficiency T cell-negative/B cell-positive/NK cell-positive (T (-) /B (+) /NK (+) SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms, including Candida albicans, Pneumocystis carinii, and cytomegalovirus, among many others. The common characteristic of all types of SCID is absence of T cell-mediated cellular immunity due to a defect in T-cell development.