PTPRN polyclonal Antibody | BS8189

PTPRN polyclonal Antibody | BS8189 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:100

Background: Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins,membrane-associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPα, PTPβ, PTPγ, PTPδ, PTPε, PTPζ, PTPκ and PTPμ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain and an extracellular Nterminus.Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis. PTP IA-2 is an autoantigen and contributes to Insulin-dependent diabetes mellitus (IDDM) . The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PTPRN polyclonal Antibody detects endogenous levels of PTPRN protein.

Molecular Weight: ~ 66 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

Immunogen: Recombinant full length Human PTPRN.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: