Purified Anti-Human FOXP3 Monoclonal Antibody | DL20224F

Purified Anti-Human FOXP3 Monoclonal Antibody | DL20224F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Forkhead box protein P3, FOXP3, Scurfin, Forkhead box protein P3 41 kDa form, IPEX

Reactivity: Human

Application: ICFCM

Background: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25) . Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.

Concentration: 0.2 mg/mL

Conjugation: Unconjugated

Buffer: PBS with 0.05% Proclin300

Clone: 236A/E7

Isotype: Mouse IgG1, κ