PVR polyclonal Antibody | BS7837

PVR polyclonal Antibody | BS7837 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: CD155, a member of the immunoglobulin superfamily, acts as the human receptor for poliovirus (PV) . All three serotypes of PV- PV1, 2, and 3- exhibit similar binding to CD155 in both its glycosylated and fully deglycosylated forms, indicating they utilize a common mechanism for cell entry. Additionally, CD155 undergoes cell-matrix contacts by binding to the matrix protein vitronectin. Along with the receptor form, three soluble isoforms, α β, and γ, also exist in human serum and cerebrospinal fluid, and CD155 mRNAs are highly expressed in liver tissue. The presence of soluble CD155 reduces polivirus entry mediated by the membrane-bound receptor, implying an important role for these soluble forms in cellular function.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PVR polyclonal Antibody detects endogenous levels of PVR protein.

Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD155; CD155 antigen; HVED; mE4; NECL 5; Necl-5; Necl5; Nectin like 5; Nectin like protein 5; Nectin-like protein 5; Ortholog of mouse Tage4; Poliovirus receptor; PVR; PVS; Taa1; Tage 4; TAGE4;

Immunogen: Recombinant full length Human PVR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: