PVRL1 Polyclonal Antibody | BS65668

PVRL1 Polyclonal Antibody | BS65668 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Cow,Rabbit,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human Nectin is identical to the poliovirus receptor-related protein (PRR) and is identified to be the alphaherpesvirus entry mediator. Nectin constitutes a family consisting of at least nectin 1, 2 and 3. Nectin 2 and 3 are ubiquitously expressed, whereas nectin 1 is abundantly expressed in the brain. Nectin 1 exists as nectin 1å and 1∫/HIgR, produced by alternative splicing. The cytoplasmic regions of Nectin 1å, but not Nectin 1∫/HIgR, have a C-terminal conserved motif (E/A-X-Y-V) . This motif interacts with the PDZ domain of the F-Actin-binding protein, afadin, through which it is linked to the Actin cytoskeleton. Nectin 1, also designated HveC/ PRR1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with nectin 1 is an essential step in the process leading to membrane fusion; the gD binding site is located at the first Ig-like domain of Nectin 1. Both the transinteraction of nectin and the interaction of nectin with afadin are necessary for their co-localization with E-cadherin and catenins at adherens junctions.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PVRL1 Polyclonal Antibody detects endogenous levels of PVRL1 protein.

Molecular Weight: 54kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD111; CD111 antigen; CLPED1; ectodermal dysplasia 4 (Margarita Island type) ; ED4; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig like receptor; Herpesvirus Ig-like receptor; HIgR; HveC; Nectin 1; Nectin-1; Nectin1; OFC7; OROFACIAL CLEFT 7; Poliovirus receptor related protein 1; poliovirus receptor-like 1; Poliovirus receptor-related protein 1; PRR; PRR1; PVRL 1; PVRL1; PVRL1_HUMAN; PVRR; PVRR1; SK-12.

Immunogen: KLH conjugated synthetic peptide derived from human PVRL1/CD111/Nectin1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: