PX-478 hydrochloride | B1033

PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.

PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.

B1033 | PX-478 hydrochloride DataSheet

Alternate Name/Synonyms: (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride

Appearance: Brown solid

Formulation: N/A

CAS Number: 685898-44-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₂₀Cl₄N₂O

Molecular Weight: 394.11

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O (> 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A HIF-1α inhibitor

MDL Number: N/A

PubChem CID: 11234794

SMILES: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

InChi: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1

InChi Key: GIGCDIVNDFQKRA-LTCKWSDVSA-N