Quinidine Sulfate dihydrate | 2910

Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.

Quinidine sulfate dihydrate is a Na+ channel blocker and a class I antiarrhythmic drug. It is a substrate of P-glycoprotein also an inhibitor of the cytochrome P450 enzymes 2D6, 3A4.

2910 | Quinidine Sulfate dihydrate DataSheet

Alternate Name/Synonyms: Conquinine; β-Quinine

Appearance: White to off-white powder

Formulation: N/A

CAS Number: 6591-63-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Sulfate

Molecular Formula: (C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O

Molecular Weight: 782.9

Cell-Permeable?: No

Purity: ≥97% by HPLC

Solubilities: DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A P-glycoprotein substrate, Cytochrome P450 inhibitor

MDL Number: MFCD00149346

PubChem CID: 16219922

SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O

InChi: InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1

InChi Key: ZHNFLHYOFXQIOW-WFTMRWCJSA-N