R-7050 | B3063

R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor interacting protein 1 (RIP1) through inhibition of ligand-induced receptor endocytosis. It inhibits TNFα-induced intercellular adhesion molecule 1 (ICAM-1) expression with an EC₅₀ of 0.631 µM. It (6-12 mg/kg) improves neurovascular injury after intracerebral hemorrhage in mice.

R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor interacting protein 1 (RIP1) through inhibition of ligand-induced receptor endocytosis. It inhibits TNFα-induced intercellular adhesion molecule 1 (ICAM-1) expression with an EC₅₀ of 0.631 µM. It (6-12 mg/kg) improves neurovascular injury after intracerebral hemorrhage in mice.

B3063 | R-7050 DataSheet

Alternate Name/Synonyms: TNF-alpha Antagonist III; 8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline; 8-chloro-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxalin-4-yl phenyl sulfide

Appearance: Beige to Yellow Solid

Formulation:

CAS Number: 303997-35-5

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₆H₈ClF₃N₄S

Molecular Weight: 380.77

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~10 mg/ml in DMF; ~1 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of signaling through the TNFα receptor complex

MDL Number: MFCD00140737

PubChem CID: 1486608

SMILES: C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F

InChi: InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H

InChi Key: SUUMKHOVGVYGOP-UHFFFAOYSA-N