RA-9 | B3358

RA-9 | B3358

Description: RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor that displays favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors.

Alternate Name/Synonyms: RA9 (3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone

Appearance: Solid

Formulation:

CAS Number: 919091-63-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₅N₃O₅

Molecular Weight: 365.34

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >4 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! by all modes of exposure.

Tag Line: An ubiquitin-proteasome system (UPS) inhibitor

MDL Number:

PubChem CID: 5469266

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/5469266

SMILES: C1C(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])CN1

InChi: InChI=1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+

InChi Key: YUYPWAMLWZVHAE-KAVGSWPWSA-N

Category: Biochemicals