Rabbit Anti-BEBOV GP

Product name:

Anti-REBOV GP antibody

Description:

Rabbit polyclonal to REBOV GP

Host species:

Rabbit

Specificity:

ab190658 detects recombinant REBOV GP without the transmembrane region (REBOV rGPdTM). No cross reactivity to Sudan ebolavirus (SEBOV) GP, Zaire ebolavirus (ZEBOV) GP, Bundibugyo (BEBOV) GP or Marburg (MARV) GP, was observed in Western blot analysis.

Species reactivity:

Species independent

Immunogen:

Synthetic peptide corresponding to REBOV GP. (Reston Ebola virus glycoprotein)

Form:

Liquid

Storage instructions:

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Storage buffer:

Constituent: 100% PBS

Concentration:

50 µg at 1.92 mg/ml

Purity:

Immunogen affinity purified

Clonality:

Polyclonal

Isotype:

IgG

Cellular localization:

Secreted

Relevance:

REBOV GP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils. Delta-peptide does not seem to be involved in activation of primary macrophages B REBOV GP is a homodimer; disulfide-linked. The homodimers are linked by two disulfide bonds in a parallel orientation. Delta-peptide is a monome.