Rac1/2/3 polyclonal Antibody | BS91142

Rac1/2/3 polyclonal Antibody | BS91142 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity) . Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Rac1/2/3 polyclonal Antibody detects endogenous levels of Rac1/2/3 protein.

Molecular Weight: 21/24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: p21-Rac1, p21-Rac2, p21-Rac3, Cell migration inducing gene 5 protein, EN 7, OTTMUSP00000004488, p21 Rac3, p21-Rac3, Rac1B, RAC3, RAC3, RAS related C3 botulinum substrate 3, Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3), Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), Ras-related C3 botulinum toxin substrate 3, Rho family small GTP binding protein Rac3, RP23-84C12.18, EN-7, EN7, GX, HSPC 022, HSPC022, p21 Rac 2, p21 Rac2, p21-Rac2, p21Rac2, RAC 2, Rac2, RAC2, Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2, Ras related C3 botulinum toxin substrate 2, Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2), Ras related C3 botulinum toxin substrate 3, Ras-related C3 botulinum toxin substrate 2, Rho family small GTP binding protein Rac 2, Rho family small GTP binding protein Rac2, Small G protein, Cell migration-inducing gene 5 protein, MGC111543, MIG5, Migration inducing gene 5, Migration inducing protein 5, p21 Rac1, p21-Rac1, Rac 1, RAC1, RAC1, Ras like protein TC25, Ras related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Ras-like protein TC25, Ras-related C3 botulinum toxin substrate 1, Rho family small GTP binding protein Rac1, TC 25, TC25,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: