RAD21 Antibody (C-Term) [ApR05016G]

RAD21 Antibody (C-Term) [ApR05016G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This RAD21 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-535 amino acids from human RAD21.

Cellular Localisation: [Double-strand-break repair protein rad21 homolog]: Nucleus. Nucleus matrix Chromosome Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with chromatin (PubMed:11590136, PubMed:11073952) . Before prophase, scattered along chromosome arms (PubMed:11073952) . During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760) . A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732)

Molecular Weight: 71690

Clone: Polyclonal

Gene Name: RAD21

Gene ID: 5885

Function: [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732) . The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136) . In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity) . May control RUNX1 gene expression (Probable) . Binds to and represses APOB gene promoter (PubMed:25575569) . May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity) .

Summary: Tissue Location: Expressed in the gut (at protein level) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, HR21, KIAA0078, NXP1