RAD50 Polyclonal Antibody | E-AB-12632

RAD50 Polyclonal Antibody | E-AB-12632 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: DNA repair protein RAD50, hRAD50, hsRAD50, Mrell, NBSLD, Rad 50, RAD50 2, rad50, RAD50 homolog (S cerevisiae), RAD50 homolog, RAD50 PEN, RAD50, S. cerevisiae, homolog of, RAD50, RAD502, Rad50l, Truncated RAD50 protein

Application: WB, IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Concentration: 0.4 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human RAD50

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 154 kDa

Molecular Weight(Observed): N/A