RANGAP1 Antibody (N-term) [APR31158G]

RANGAP1 Antibody (N-term) [APR31158G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.

Cellular Localisation: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602) . Targeted to the nuclear pores after sumoylation (PubMed:11854305) . During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602) . Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305) . Mitotic location also requires sumoylation (PubMed:11854305) .

Molecular Weight: 63542

Clone: Polyclonal

Gene Name: RANGAP1

Gene ID: 5905

Function: GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860) . Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050) . Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050) .

Summary: Tissue Location: Highly expressed in brain, thymus and testis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD