RANKL (A72) polyclonal Antibody | BS1867

RANKL (A72) polyclonal Antibody | BS1867 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:1000 IF: 1:50~1:200

Background: Members of the tumor necrosis factor (TNF) receptor superfamily interact with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate the NFκB and JNK pathways. RANK (receptor activator of NFκB) is a member of the TNFR family identified on dendritic cells. This type I membrane receptor is expressed in a broad range of tissues. The C-terminus of RANK is required for RANK to bind TRAF2, 5 and 6, and it is also necessary for stimulating NFκB activation. The ligand for this receptor, RANKL (also designated TRANCE, OPGL or ODF), is a type II transmembrane protein expressed primarily in lymphoid tissues and T cell lines. RANKL appears to be an important regulator of T cells and osteoclasts.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RANKL (A72) polyclonal Antibody detects endogenous levels of RANKL protein.

Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; CD254; TNFSF11; OPGL; RANKL; TRANCE

Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human RANKL.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A