Rapamycin | 1568

An immunosuppressant. Selectively blocks signaling that leads to p70 S6 kinase activation (IC₅₀ = 50 pM). Inhibits lymphokine-induced cell proliferation at the G1 phase. Induces apoptosis in a murine B cell line. Rapamycin has been used in vivo studies by i.p., i.m., and i.v. administrations..

Rapamycin is an immunosuppressant that selectively blocks signaling that leads to p70 S6 kinase activation (IC₅₀ = 50 pM).

1568 | Rapamycin DataSheet

Alternate Name/Synonyms: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus

Appearance: White to Off-white solid

Formulation: N/A

CAS Number: 53123-88-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅₁H₇₉NO₁₃

Molecular Weight: 914.19

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO and EtOH

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An immunosuppressant

MDL Number: MFCD00867594

PubChem CID: 5284616

SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

InChi: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChi Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N