RASA4 polyclonal Antibody | BS60215

RASA4 polyclonal Antibody | BS60215 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: RASA4 (ras GTPase-activating protein 4) is an 803 amino acid member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogenactivated protein kinase pathway in response to Ca2+. Stimuli that increase intracellular Ca2+ levels result in the translocation of the RASA4 protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth and differentiation. Containing 21 exons and spanning 35 kb of genomic DNA, RASA4 includes one Btk-type zinc finger, two C2 domains, one PH domain and one Ras-GAP domain.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RASA4 polyclonal Antibody detects endogenous levels of RASA4 protein.

Molecular Weight: ~ 85, 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ras GTPase-activating protein 4; Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2; CAPRI; GAPL; KIAA0538

Immunogen: A synthetic peptide corresponding to residues in Human RASA4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: