Rat Anti-Human BMP-1 Antibody | 101-M231

Rat Anti-Human BMP-1 Antibody | 101-M231 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#11B23)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: BMP1; PCP; TLD; PCP2; PCOLC

Isotype: IgG2

Application: WB, IHC

Detection Range: WB: 1:200-1000, IHC: 1:50-100

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human BMP-1

Description: Bone morphogenetic protein 1 (BMP1), also known as procollagen Cproteinase (PCP), is a zinc protease of the astacin family. BMP1/ PCP plays a key role in formation of extracellular matrix (ECM) by converting precursor proteins into their mature and functional forms. The precursor proteins identified as substrates for BMP1/ PCP include collagens, biglycan, laminin 5, dentin matrix protein1, and lysyl oxidase. There are six alternatively spliced forms known to be derived from the BMP 1 gene, and isoform 1 consisting of residues 1 to 730 was expressed. The secreted and purified protein does not contain the signal peptide (amino acid residues 122) and pro domain (residues 23-120), but contain protease (residues 121-321), CUB I (residues 322-434), CUB II (residues 435-546), EGFlike (residues 547-588) and CUB III (residues 591-703) domains. The pro domain is apparently cleaved by a furinlike proprotein convertase. The purified BMP1/ PCP is an active protease and its peptidase activity can be determined as described above. The purified BMP1/ PCP is predicted to possess procollagen C proteinase activity because it contains the minimal domain structure required.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 649