Rat Anti-Mouse ALK4 (Activin R1B) Antibody | 103-M212

Rat Anti-Mouse ALK4 (Activin R1B) Antibody | 103-M212 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#8J28)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Acvr1b; Alk4; SKR2; ActRIB; ActR-IB; Acvrlk4; 6820432J04

Isotype: IgG2

Application: WB, IHC

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse ALK4 extracellular domain

Description: Activin RIB, also known as ALK4, is a glycosylated 58 kDa type I transmembrane receptor that belongs to the superfamily of TGFβ serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules. These ligands bind to Activin RIIB which then associates with, and phosphorylates, the cytoplasmic domain of Activin RIB to initiate signal transduction. Mature mouse Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain. Within the ECD, mouse Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB, respectively. It shares 23% 38% aa sequence identity with other mouse type I receptors Activin RIA, BMPRIA, BMPRIB, and TGFβ RI. Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein. Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan (8). Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation, apoptosis, and tumorigenesis.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 11479