Rat Anti-Mouse Cardiotrophin-1 Antibody | 103-M309

Rat Anti-Mouse Cardiotrophin-1 Antibody | 103-M309 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#1J24)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Ctf1; CT-1

Isotype: IgG1

Application: WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse Cardiotrophin-1

Description: Cardiotrophin1 (CT1) is a member of the cytokine family which also includes IL6, IL11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL6 family members on a variety of cell types. Mouse CT1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT 1 release from cells is currently not understood. Human and mouse CT1 share 80% aa sequence identity and exhibit crossspecies activity. CT1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT1 expression is also seen in testis and brain. CT 1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit. A third α receptor subunit has also been implicated in the receptor complex.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 13019