Rat Anti-Mouse HGF Activator Inhibitor Type 1 (HAI-1) Antibody | 103-M229

Rat Anti-Mouse HGF Activator Inhibitor Type 1 (HAI-1) Antibody | 103-M229 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#3G21)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Spint1; HAI-1

Isotype: IgG2

Application: WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse HAI-1 extracellular domain

Description: Hepatocyte growth factor activator inhibitor1 (HAI1) encoded by the Spint1 gene is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGF-A) and matripas. The membraneanchored HAI1 consists of two Kunitz domains, a LDL-recepto-rlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface. The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12myristate, 13acetate or IL1β. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 20732