Rat Anti-Mouse TREM-1 Antibody | 103-M279

Rat Anti-Mouse TREM-1 Antibody | 103-M279 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#3C66)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: TREM1

Isotype: IgG2

Application: WB, IHC (F)

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse extracellular domain of TREM-1

Description: TREM1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Iglike domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM1 is expressed on blood neutrophils and a subset of monocytes, and expression is upregulated by bacterial LPS. Engagement of TREM1 with a monoclonal antibody leads to expression of IL8, MCP1, and TNFα suggesting that this receptor plays an important role in inflammatory responses. TREM1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS induced shock. Blockade of TREM1 with a TREM1/ Fc fusion protein protected mice against LPS induced shock.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 58217