RAT Camk2a Antibody (ascites) [AMR09698G]

RAT Camk2a Antibody (ascites) [AMR09698G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: Rat

Specificity: Purified His-tagged Camk2a protein (Fragment) was used to produced this monoclonal antibody.

Cellular Localisation: Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts

Molecular Weight: 54115

Clone: Monoclonal

Gene Name: Camk2a

Gene ID: 25400

Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654) . Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity) . Acts as a negative regulator of 2-arachidonoylglycerol (2-AG) -mediated synaptic signaling via modulation of DAGLA activity (By similarity) .

Summary: N/A

Form: Rat monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000~8000

Synonyms: Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a