RBC8 | B1136

RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the activation of RaiA in living cells Ral is needed for the growth of murine embryonic fibroblasts (MEFs). Ral pull down assay showes that RBC8 inhibits the activation of both RalA and RalB in the H2122 and H358 cell lines.

RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the activation of RaiA in living cells Ral is needed for the growth of murine embryonic fibroblasts (MEFs). Ral pull down assay showes that RBC8 inhibits the activation of both RalA and RalB in the H2122 and H358 cell lines.

B1136 | RBC8 DataSheet

Alternate Name/Synonyms: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

Appearance: White Solid

Formulation: N/A

CAS Number: 361185-42-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₀N₄O₃

Molecular Weight: 424.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: RalA and RalB GTPase inhibitor

MDL Number: N/A

PubChem CID: 6626226

SMILES: COC1=CC(=C(C=C1)OC)C2C(=C(OC3=NNC(=C23)C4=CC5=CC=CC=C5C=C4)N)C#N

InChi: 1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)

InChi Key: CLMQBVUFKIKYLU-UHFFFAOYSA-N