RBFOX3 Polyclonal Antibody | E-AB-12595

RBFOX3 Polyclonal Antibody | E-AB-12595 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: FLJ56884, FLJ58356, Fox-1 homolog C, fox1 homolog C, Fox3, FOX3NeuN, hexaribonucleotide binding protein 3, HRNBP3, NEUN, neuronal nuclei, Rbfox3, RFOX3, RNA binding protein fox-1 homolog 3, RNA binding protein, fox 1 homolog (C. elegans) 3

Application: WB, IHC, ELISA

Reactivity: Human , Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Tags and Cell Markers

Background: Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

Concentration: 0.1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human RBFOX3

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000 IHC 1:50-200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 34 kDa

Molecular Weight(Observed): Refer to figures